World Nutraceutical Conference and Expo July 13-15, 2015 Philadelphia, USA

Biography:

Prof. Sinerik Ayrapetyan has completed his Ph.D in Cell Biophysics in the Bogomolets Institute of Physiology (NAS of Ukraine). He is the coordinator of UNESCO Chair and head of Research Council of Life Sciences International Postgraduate Educational Center. His current research interest is “Intracellular Signaling System in Norm and Pathology”. On this subject he has published 7 international books and 115 papers. He is a member of the board of associate editors for the journals: “Electromagnetic Biology and Medicine”, “ISRN Biophysics” and a member of editorial board for the journals: “Advances in Life Sciences”, “Bioavailability and Bioequivalence”, “Applied Pharmacy”, “European Journal of Biophysics”, “Biochimica et Biophysica Acta” , “Journal of International Dental and Medical Research”. He is a member of International Coordination Council of WHO and number of professional international societies.

Abstract:

Age-induced medical disorders are modern problems in medicine and have become a focal point for public health concern due to the aging of the world population. The main barrier for solving this problem is, in the literature available for us, the absence of a reliable, universal biomarker for detection of the functional state of the whole organism though there are different methods for detection of the functional state of individual organs. We believe that metabolic controlling of cell hydration could serve as a universal biomarker for estimation of the effect of different chemical and physical factors, including food and drinking water, on the functional state of the organism. By our previous study it was shown that cell pathology, including aging, leads to the dysfunction of Na+/K+-ATPase α3 isoform-dependent intracellular signaling system controlling cell hydration. Therefore, we suggest that that activation of α3 isoform-dependent cell hydration could serve as a marker for estimation of bioavailability of food and drinking water. For this purpose elaboration of a new non-invasive device with corresponding software for detection of muscle hydration based on frequency-dependent characteristics of muscle impedance is suggested. The experimental data that prove our suggestion will be demonstrated in the lecture.

Biography:

Prof. Sinerik Ayrapetyan has completed his Ph.D in Cell Biophysics in the Bogomolets Institute of Physiology (NAS of Ukraine). He is the coordinator of UNESCO Chair and head of Research Council of Life Sciences International Postgraduate Educational Center. His current research interest is “Intracellular Signaling System in Norm and Pathology”. On this subject he has published 7 international books and 115 papers. He is a member of the board of associate editors for the journals: “Electromagnetic Biology and Medicine”, “ISRN Biophysics” and a member of editorial board for the journals: “Advances in Life Sciences”, “Bioavailability and Bioequivalence”, “Applied Pharmacy”, “European Journal of Biophysics”, “Biochimica et Biophysica Acta” , “Journal of International Dental and Medical Research”. He is a member of International Coordination Council of WHO and number of professional international societies.

Abstract:

Age-induced medical disorders are modern problems in medicine and have become a focal point for public health concern due to the aging of the world population. The main barrier for solving this problem is, in the literature available for us, the absence of a reliable, universal biomarker for detection of the functional state of the whole organism though there are different methods for detection of the functional state of individual organs. We believe that metabolic controlling of cell hydration could serve as a universal biomarker for estimation of the effect of different chemical and physical factors, including food and drinking water, on the functional state of the organism. By our previous study it was shown that cell pathology, including aging, leads to the dysfunction of Na+/K+-ATPase α3 isoform-dependent intracellular signaling system controlling cell hydration. Therefore, we suggest that that activation of α3 isoform-dependent cell hydration could serve as a marker for estimation of bioavailability of food and drinking water. For this purpose elaboration of a new non-invasive device with corresponding software for detection of muscle hydration based on frequency-dependent characteristics of muscle impedance is suggested. The experimental data that prove our suggestion will be demonstrated in the lecture.

Biography:

Anna Michalska has completed her PhD at the age of 29 years from Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn (Poland) and postdoctoral studies from HESSO Valais-Wallis University of Applied Sciences and Art in Sion (Switzerland). Meanwhile, she was attended a scholarship ‘TOP500 Innovators – science, management, commercialization’ at Stanford University (CA, USA). Currently, she is working at Wroclaw University of Environmental and Life Sciences as an assistant professor. She has published more than 20 papers in journals with IF and has been serving as an associate editor of International Journal of Food Engineering (De Gruyter).

Abstract:

Currently, powdered form of fruits has received a special attention as reducing water content in powders increases shelf life and extends the availability of fruits throughout the year, being a valuable source of bioactive compounds, including antioxidants. Processing involved in the production of blackcurrant powders is a multi-step and time-consuming procedure that may influence the functional properties of the products obtained. In the present study, the possible ways of formulation of blackcurrant powders were presented. A comparison of blackcurrant powders gained by selected drying methods was shown in relation to changes in the content of nutritional bioactive compounds and antioxidant capacity against the quality of dehydrated products. The application of high-temperature drying methods was performed in comparison to the freeze-drying process. The properties of powders were characterized by physical parameters providing data on their handling and storage properties. The data obtained showed the ways of retention of major bioactive compounds by modulating the processes applied for blackcurrant powders production that may be used as nutraceuticals with a broad range of applications.

Biography:

Nalin Siriwardhana is a Senior Medical Scientist with proven track records of both academic and industrial careers. He has expertise in applications of nutraceuticals for a wide array of health conditions including heart, digestive, bone, joint, immune, diabetes, cancer, cognition, eye and sleep complications. Followed by a successful academic career as a Research Assistant Professor at the University of Tennessee and Texas Tech University, he has joined RB as a Senior Associate-Global Medical & Innovation - VMS. He has published more than 20 scientific articles. He has presented more than 30 times at Nutrition Science Conferences. In his current role at RB, he contributes his medical and nutrition science expertize for product innovations, global launches, medical claims and medical detailing. Also, he is the founder of HONcode certified website ‘www.nutritionremarks.com’ which publishes health and nutrition news based on scientific evidence.

Abstract:

Omega-3 fatty acids are essential nutrients for the human body. Despite a few recent controversial scientific reviews and meta-analysis regarding the benefits of omega-3s, the global omega-3 market has been projected to reach upto $34B in 2016. Furthermore, there is continuous and growing interest towards further exploring the science behind omega-3s. The number of scientific studies appearing in PubMed has exceeded 21,000 publications. Also, there is a critical knowledge gap of properly designed clinical studies linking individual variability in utilization of omega-3s with long term benefits. This presentation discusses the major mechanisms by which omega-3 delivers health benefits, both positive and negative consistent outcomes from clinical studies, and scientific facts contributed to why omega-3s have been regarded amongst the top nutrients of all time. In modern western diet, the ratio between omega-3 and omega-6 is over 1:20, whereas human beings evolved on a diet with a ratio of approximately 1:1 or 1:2. This change has occurred within an extremely short time period as compared to the evolutionary time scale of the human genome. Given the well-established importance of gene-nutrient compatibility, the dramatic shift of the omega-3 to omega-6 ratio may be the underlying reason for many chronic diseases. Therefore, intake of nutrients compatible with our genome may ensure proper and efficient functioning of the human body, thus contributes towards the prevention of a variety of diseases.

Biography:

Jat Rana earned his Masters of Science in Applied Organic Chemistry and PhD in Organic Chemistry from Birmingham University, England (UK). He has done his Post-doctoral fellow at the University of Glasgow, Scotland (1981) and USDA Research fellow at University of Minnesota, Minneapolis (1985). Production Manager at the Sigma-Aldrich Corporation in St. Louis, MO (1985-1996). In 1996 he joined the Nutraceutical R&D group at Amway Corporation in Ada, Michigan, where he continues to provide his expertise in Natural products / Herbal chemistry and Asian traditional medicine. Discovery of innovative ingredients from plants for health & beauty application is his passion. He has published many scientific papers in peer reviewed journals.

Abstract:

Use of botanicals for improving or to care for human health has evolved independently in different countries worldwide. In the scientific area, botanical products are generally intended as drugs, medicinal products, food supplements, or substances for therapeutic use derived from raw material of whole plants or parts of them. With the recent advent of high-throughput screening technologies, experimental analyses of the active ingredients and their mechanisms of action have become increasingly important along with the standardization of botanicals. After thousands of years of clinical practice and high-throughput screening & evaluation, scientists have discovered a variety of botanical ingredients possessing medicinal value. With accumulated experience and knowledge, the relationship between efficacy of ingredient and certain diseases or symptoms was gradually established. This presentation will focus on examples of various biological screening & extraction technology platform implemented for the discovery of innovative science based functional botanical ingredients for the development of Weight Management. This presentation will be of great interest to various R&D scientists looking for the innovation in ingredient technology and consumers who use new and innovative products.

Biography:

In 2011, in recognition of her accomplishments, Dr. Abdel-Massih was named by The World Academy of Sciences (TWAS) a “TWAS Young Affiliate” for a period of five years. Based in Trieste, TWAS works to advance scientific work that contributes toward sustainable prosperity in the developing world. The author of 19 publications in peer reviewed journals; Dr. Abdel-Massih is currently studying the biological activity of plant products, looking for anti-bacterial molecules within plant extracts. Her focus is on the biotransformation of molecules and the effect of Lebanese plant extracts on multi-drug

Abstract:

Pectin is a heterogeneous polysaccharide mainly present in citrus fruits and has different biological activities. Its chemical composition and structure varies between different plant sources and even in different parts of a plant. In this study, the cytotoxicity, anti-proliferative, and antimicrobial activity of citrus pectin (high molecular weight pectin) and modified citrus pectin (MCP) were investigated. Cytotoxicity of various concentrations of pectin and MCP was studied against HaCaT cell line (human keratinocyte cell line) using Trypan blue method and LDH-cytotoxicity assay. Anti-proliferative activity was assayed using a WST-1 proliferation kit. MCP and Pectin both reduced the viability of HaCat cells in a dose dependent manner; however MCP was found to be more cytotoxic than high molecular weight citrus pectin since it had a lower IC50 (300ug/ul).MCP was also more capable of inhibiting HaCat proliferation than pectin. The antibacterial activity of citrus pectin and MCP was investigated against reference strains and clinical isolates of Staphylococcus aureus and extended spectrum beta-lactamase (ESBL) producing Escherichia coli. Broth micro dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibacterial activity of pectin varied according to the source of the pectin extract, the pH used, and the molecular weight of pectin. The greatest antibacterial activity was observed with pectin at pH 6. The MIC values against S. aureus ranged between 0.39–3.125 mg/ml and the MBC values ranged between 3.125– 12.5mg/ml. Modified Citrus Pectin (MCP) exhibited lower antibacterial activity with MICs of 25-50 mg/ml and MBCs were equal or higher than 50 mg/ml. Pectin exhibited lower antibacterial activity against E. coli with MICs of 25 and 50 mg/ml and MBCs ranging between 25 and 50 mg/ml. The conclusions from this study suggest that MCP exhibit a higher anti-proliferative effect on HaCaT cell line whereas pectin showed a stronger antibacterial activity against S. aureus, a major Gram positive pathogen. The most probable explanation of this observation is the different effect due to the variable length, molecular weight, and exposed side-chains of MCP and high molecular weight citrus pectin. For that they merit further investigation as a potential therapeutic agent.

Biography:

Dr. Parimelazhagan Thangaraj, is Associate Professor in the Department of Botany, School of Life Sciences, Bharathiar University, Coimbatore. His areas of specialization include Bioprospecting of medicinal plants. He has worked as Scientist in DRDO, Govt. of India. He has filed four patents and has more than 35 research publications to his credit. He is working on natural products for the past 10 years and guiding 8 Ph.D. scholars. His book ‘Herbal Perspective: Present and Future’ is an excellent reference book for those biologists and pharmacy students. He has four books to his credit on various aspects of medicinal plants and filed 4 patents. He has bagged National Science Day Medal 2005 from DRDO HQ, New Delhi and Laboratory Scientist of the Year award 2005 from DRDO.

Abstract:

Syzygium calophyllifolium belongs to the family Myrtaceae. It is endemic to the medicinal wealth of Western Ghats of India and used as wild edible, rich in essential nutrients fruit by tribal peoples due to its traditional medicinal properties. S. calophyllifolium fruit and bark is placed in the aching tooth and inflammation for relief. Seed extract has shown profound antidiabetic effect. The present investigation was carried out to evaluate the antioxidant activity and nutritional content of S. calophyllifolium fruit. The extraction was carried out in Soxhlet apparatus using petroleum ether, ethyl acetate, methanol and, finally, with hot water maceration. Methanol extract of fruit showed good nitric oxide radical scavenging (65.6%) and metal chelating activity (44.1 mg EDTA equivalents/ g extract). The analysis of amino acid was done using amino acid analyzer (HPLC- LC 10 AS). It was found that almost all essential and non-essential amino acids were present with arginine (8.4 % of protein) and cysteine (7.4 % of protein) in highest amounts. The results were compared with WHO/FAO recommended levels of amino acids. The mineral estimation showed the presence of calcium (12200 part per million) nitrogen (8800 part per million) in superior quantity when compared to other minerals. High amount of proteins (20.45 g/100g) and carbohydrates (41.35 g/100g) were also estimated in this fruit. This is the first report on the nutritional composition of S. Calophyllifolium which will enhance its importance as a source of medicinal food, and help in the exploration of nutraceutical properties of the fruit with its wide commercialization in Indian as well as International market.

Biography:

Nitika has completed her Graduation in Pharmacy in 2015 from the Khalsa College of Pharmacy, Punjab, India. During her Graduation, she has been successful in publishing one review article in a reputed journal and also got an opportunity to attend an International Conference on Advances in Pharmaceutical Nanotechnology and Nanomedicine (ICPNN-2015).

Abstract:

Nutraceuticals is combination of two words ‘nutrition’ and ‘pharmaceuticals’, invented by Stephen L. DeFelice in 1989. Nutraceuticals can be considered as food or as a part of food which plays a vital role in maintaining the health status, regulating immunity and thus treating as well as curing of a various diseases like cardiovascular disease, neurological disease, diabetes etc. By increasing awareness levels about health and fitness, urged by media coverage are prompting the majority of masses to lead healthier lifestyles. In a growing percentage of vascular disease etiologies, atherosclerosis is one of the most common ailments observed. Polyunsaturated Fatty Acids are found to reduce the formation of thromboxane and hence, are useful as preventive measures for atherosclerosis. Omega-3-fatty acids have been found to be useful for the reduction of LDL and VLDL levels and increase in physicochemical stability of cell wall. Besides, nutraceuticals exhibit an anti-inflammatory and anti-oxidative properties as well which provide useful measures for preventing and treating diabetic complications. There are a wide variety of neuro-degenerative diseases with different symptoms and pathologies which can be cured by nutritional supplements. Oxidative stress plays a fundamental role in aging and neurodegeneration. In recent studies, it has been proved that blueberries have found with highest antioxidant content which act by normalize sensitivity to neurotransmitters and promote synaptic plasticity.

Biography:

Michael Dodson is a medical graduate who has completed a PhD and masters degrees in public health and health management.A previous senior medical advisor and Office head at the Australian Therapeutic Goods Administration, he spent two years as Associate Dean for the University of Notre Dame Australia clinical school in Melbourne before taking up the role of Medical Director for Blackmores, Australia’s most trusted nutraceutical company. Dr Dodson is currently a member of the Australian Advisory Committee on Non-Prescription Medicines and is an Adjunct Associate Professor at the University of Western Sydney.

Abstract:

Non-communicable diseases (NCD) are the leading cause of mortality worldwide. Obesity is a key risk factor for NCD and accounts for significant morbidity, mortality and economic costs. The prevalence of obesity has increased over the past 30 years and is likely to increase further in the coming decade. This is likely related to the complex interplay of biological, behavioural, psychological, social and environmental influences, and the lack of perceived risk of the disorder in relation to health outcomes. These factors also combine to produce a condition that is difficult to prevent and difficult to treat. Population based strategies provide a cost effective and potentially highly effective way of tackling highly prevalent conditions such as obesity and relatively small changes in population BMI is likely to be associated with significant health benefits and health care savings across the population. Nutraceutical products sit at the interface between pharmaceuticals and foods. Generally low risk, they are available for self-selection by consumers and therefore can be marketed broadly to the population. Products able to help individuals achieve a tangible degree of weight-loss, that are taken up by a significant proportion of the general population are potentially able to deliver significant health benefits and healthcare savings- particularly if these can be integrated into a program of lifestyle change. A snapshot of nutraceuticals with weight-loss claims available in the Australian market is provided. The evidence supporting currently marketed products is limited but a real opportunity exists to develop, test and market effective weight loss products.

Biography:

Mark JS Miller is a unique, innovative and entrepreneurial scientist with a heady track record of success in business. With three decades of experience as a Professor and elite researcher, Dr. Miller currently approaches unmet consumer needs using the opportunities offered by natural products and nutrition. His product innovations, marketing skills and ground-breaking research has crossed numerous disciplines offering a unique scientific and global perspective.

Abstract:

As we develop more sophisticated tools to measure and monitor health and tissue function we tend to discard traditional medicines as a source of innovation. We discount experience and because they are discussed in simple language it is common to discount their value. However, the rich history of experience can be a poignant and directed teacher. Using examples of personal research on South American traditional botanicals when evaluated with modern sophisticated techniques (epigenetics, metabolomics, disease models) one can not only decipher how the traditional medicines offer benefit and the molecular basis for the traditional use, but insight can be drawn for new applications and synergism with other natural products or nutritionals. Examples to be discussed include, fertility, fish farming, inflammation, arthritis, cartilage repair, nausea and GI disorders and itch/skin disorders.

Biography:

Alok Bhushan received his PhD degree in Biochemistry in 1981 from Punjab Agricultural University. He did his Post-doctorate from Johns Hopkins University, Medical University of South Carolina and University of Vermont in USA. Following that, he joined Idaho State University in 1998 as a faculty member and during his tenure there, he served as Assistant Professor, Associate Professor, Professor and the Assistant Chair of the Department of Pharmaceutical Sciences. Currently he is Chair and Professor of the Department of Pharmaceutical Sciences at Jefferson School of Pharmacy in Thomas Jefferson University. He has over 70 publications.

Abstract:

Some flavonoids are known to exert anti-cancer effects by inhibiting cancer cell progression. Genistein, an isoflavone is bioactive and is present in plant products like soy. Epidemiological studies indicate geographic areas where there is increased human consumption of soy products have a lower incidence of cancer. Although not fully understood, there is some evidence isoflavones target tyrosine phosphorylation, topoisomerases and drug transporters. Our studies have therefore the goal of elucidating the molecular mechanisms underlying the putative anti-cancer effect of Biochanin A (5,7-Dihydroxy-4'-methoxyisoflavone, BioA), which is an isoflavone present in red clover, chick peas, soy, peanuts and many legumes. We noted BioA blocked the proliferation of glioblastoma, breast, pancreatic and oral squamous cancer cells. We observed BioA inhibited cell signaling pathways (e.g., MAP kinase, PI3kinase and mTOR) involved in tumor progression and matrix-metalloproteases, resulting in blocking invasion of the cancer cells. Angiogenesis is necessary for the progression of cancer cells to form tumors: Thus, tumors release angiogenic factors to stimulate the growth of capillaries that supply nutrients and oxygen to them. Consistent with the latter generation is our observation that chemical induced hypoxia increased expression of hypoxia-inducible factor and VEGF in C6 rat glioma cells: BioA blocked this effect and the proliferation and migration of bEnd.3 endothelial cells. BioA also sensitized glioma cells to tamador, a drug for treating glioblastoma. Our findings strongly suggest BioA present in the diet may suppress tumor growth and be used in prevention and combination chemotherapy that would lead to a better outcome of cancer treatment.

Biography:

Gagan Kaushal has completed his PhD from St. John’s University. He is presently working as an Associate Professor in Pharmaceutics at Thomas Jefferson University. Prior to this, he served Associate Professor at University of Charleston, Postdoctoral Associate at University of the Sciences in Philadelphia, and Senior Research Scientist, Formulations at Biosyn Inc. His expertise includes drug delivery systems, formulation development, pharmacokinetics, controlled drug delivery, drug stability, and drug solubility. His interests are focused on compounding, formulation development, stability studies, bio-analysis, and pharmacokinetic studies. He also has two Investigational New Drug Applications (INDA) approved by FDA.

Abstract:

Capsaicinoids are the compounds that give pungency to peppers. Capsaicinoids trigger pain receptors in mammals. However, long-time exposure to capsaicinoids dulls the pain receptors, making them less sensible to the compounds that trigger pain. For this reason capsaicinoids are gaining pharmaceutical use as a long-term pain reliever. Chronic back pain is the most common cause of activity limitation for people under 45 in the United States. A key point in our study is to develop value added pepper varieties adapted to local conditions. For our study, we have used a multi-disciplinary approach. At present, there is an increasing demand of vegetables with high contents of health promoting compounds in the U.S. markets. We have expanded our deliverables to include backcross derived improved varieties for various biomedical applications. Another goal of this project is the development and use of sequence based haplotyping models for cost-effective association mapping of nutraceutical traits in pepper. This method has allowed us to screen 88 accessions of Capsicum annuum. Coupling the capsaicinoids level data in the different accession to genetic studies will allow us to mine for better alleles to be used in breeding varieties with specific capsaicinoid concentrations. Two gel formulations of capsaicinoids were tested for their diffusion across rat skins. The results showed that both formulations tested diffuse capsaicinoids with over 50% efficiency.

Biography:

Dr. Aswathy Ravindran Girija is a Post-Doctoral Researcher at Bio-Nano Electronics Research Center of Graduate School of Interdisciplinary New Science in Toyo University, Japan

Abstract:

Nutraceuticals are defined as non-toxic food components extracted from foods that has scientifically established potential health benefits for disease treatment and disease prevention. Nutraceuticals that are for human consumption are marketed in concentrated forms such as capsules, pills, and powders for oral delivery and tinctures for topical applications or as suppositories containing food bioactive components. The reduced bioavailability, stability and permeability of the bioactive components in the gastrointestinal (GI) fluids leads to their partial absorption from the GI tract during their first pass metabolism. This results in their reduced or almost no biological activity, which is a major concern of the researchers today. In the conventional mode of delivery of nutraceuticals, a portion of the administered nutraceutical dose is absorbed and reaches the actual pharmacological site of action where as the remainder portion is either excreted or instigates non-specific toxicity and adverse side effects owing to undesirable bio-distribution. To overcome these problems, principles of nanotechnology have been used for the efficient delivery of nutraceuticals. The concept of nano-delivery system has emerged to acquire several modes of administration to interpret the problems associated with their absorption. There has been a significant progress in the development of nano-nutraceuticals and delivery of lipophilic nutraceuticals via nanotechnology. Effective solubilization, encapsulation, and delivery, based on nanoscience and technology, as biocompatible systems are projected to bestow them with properties like excellent absorption in lower doses, reduced frequency of administration, and amended therapeutic index. The nano-formulations also offer targeted delivery of the encapsulated nutraceuticals and also demonstrate slow and sustained release from the nano-formulation. An excellent example to demonstrate the advent of nanotechnology for the incredible enhancement in the solubility and the bioavailability of curcumin, a potential nutraceutical with several significant properties including anti-cancer potential, has been evidenced by various in vitro and in vivo studies, by the development of various nano-formulations. We have demonstrated that the encapsulation of curcumin along with magnetic nanoparticles exhibited excellent reduction in cancer cells in vitro in the synergistic with that of magnetic hyperthermia. We have also successfully encapsulated lutein, another potential nutraceutical, into polymeric nanoparticles, thus enhancing the solubility of the same. We have also developed a cream using nano-lutein and curcumin for cosmetic applications.

Biography:

Habibur Rahman is an Associate professor in the department of pharmaceutics PSG College of Pharmacy, India

Abstract:

Curcumin, a traditional herb and active ingredient of curcuma longa (Turmeric) is known for its wide pharmacological actions. Poor bioavailability of curcumin curtails the therapeutic utility of this potent molecule as drug. Lipid technology is one of the recent approaches developed to enhance bioavailability. In this line, the present study focused on the development of solid lipid nanoparticle (SLN) loaded with curcumin for enhanced bioavailability. Curcumin SLN was prepared using sterotex NF, Gelucire 33/01 and sterotex HM as lipids, Tween 80, Gelucire 44/14, PVP and propylene glycol (PG) as surfactants and co-surfactants. The developed formulations were subjected to various characterisation studies. The results suggest that the formulation prepared using Sterotex HM, Tween 80 and PG (CU5b) to be optimized formulation based on the particle size (127 nm), drug entrapment (90.40%) and in vitro drug release (82% at the end of 24 hr) analysis. The optimized curcumin SLN is subjected to pharmacokinetic and brain distribution studies in rats. The drug concentration in plasma and brain was quantified by developed HPLC method. The curcumin SLN showed more than 10 fold increases in bioavailability and dose dependent increase in bioavailability was observed for the developed optimized formulation. Based on the results it is evident that curcumin bioavailability and brain availability was promisingly improved in the form of SLN. The curcumin & SLN curcumin in both the doses was efficient in two compartment model in rat with a fitting weight coefficient of 1/C2. Further and IVIVC should be carried out to establish the nutraceutical curcumin role as drug.

Biography:

Mark J S Miller is a unique, innovative and entrepreneurial scientist with a heady track record of success in business. With three decades of experience as a Professor and elite researcher, Dr. Miller currently approaches unmet consumer needs using the opportunities offered by natural products and nutrition. His product innovations, marketing skills and ground-breaking research has crossed numerous disciplines offering a unique scientific and global perspective.

Abstract:

Taking the now established concept that as individuals we are a community, an individual can be defined as a collective of our own mammalian cells, in addition to the litany of different microbes that live on us, and in us. Approaching “self” as a community allows for us to better appreciate health and disease. We need to think beyond systems and changes in receptors/enzymes and related targets for drugs in the 20th century, to consider cellular approaches to health. In other words, what we can do to control the make-up and function of our community as a driver for health. Nutrition can play a huge part because the type of food, as well as quantity, can dictate the function and form of our bacterial community. The old adage “you are what you eat” takes on a very specific meaning. Using research examples stemming from neonates, who are the commencement of colonization, and therefore becoming their true entities, to societies who have not been exposed to antibiotics and different diets, to the chronic health issues on modern societies, we can draw attention to a critical determinant of health and disease, namely nutrient-microbiome interactions.

Biography:

Natarajan Ranganathan has been a medical researcher and entrepreneur for over thirty years. He earned two master’s degrees (organic chemistry and biochemistry) from the University of Poona, India and obtained a Ph.D. in Bio-organic chemistry from Temple University, Philadelphia. He received further academic training at the University of Pennsylvania, Hahnemann Medical College, Philadelphia, and Johns Hopkins Medical Institutions, Baltimore. Dr. Natarajan Ranganathan (Dr. Rangan), is the key founder and Managing Director (R&D) of Kibow Biotech Inc. located in Newtown Square, PA – USA. He has published more than 25 papers in reputed journals.

Abstract:

The primary goal of this talk is to update recent scientific progress, understanding, knowledge gained and also several clinical advances made since the very first review that was published in the year 2012 (Title: Probiotics, Prebiotics and Synbiotics: Gut and Beyond in Gastroenterology Research and Practice). The use of probiotics and prebiotics is generally well recognized towards digestive, gut and immune health. However, Kibow Biotech is a R&D Biotech company involved in novel and niche application of probiotics and prebiotics as a dietary supplement in stabilization of Gut Microbiome towards Chronic Kidney Disease (CKD). Since our first review article, several other reviews have been published. These independent reviews in various scientific journals reflect various topics such as gut Microbiome, its dysbiosis, impact of the altered intestinal characteristics including small bowel bacterial overgrowth, newer uremic toxins, adsorbent drugs and several observational small scale clinical studies from us and a host of others. This talk mainly connects various aspects of scientific understanding with greater emphasis on the health economics and potentials of probiotics and prebiotics towards CKD applications both in developed and developing countries. Thus, the speaker has undertaken to revisit, review and offer his independent views in connecting the failing kidney function by the bowel. This original concept is now being more scientifically researched, commercially validated and realized as “Gut and Kidney connection”.

Biography:

Devanand Luthria (Dave) is a Research Chemist in Food Composition and Methods Development Lab of the United States Department of Agriculture (USDA) Agricultural Research Service.

Abstract:

Phenolic phytochemicals are ubiquitously distributed throughout the plant kingdom and have been well studied for their bioactivities. Phenolic phytochemicals exist in multiple forms (free, conjugated, and bound insoluble). Hence, their accurate quantification is challenging. This presentation will discuss the significance of sample preparation and processing in the assay of phenolic phytochemicals in different food matrices. Systematic analysis of sequential pearled fractions of grains, potato peels and onion layers showed that phenolic compounds are not uniformly distributed in foods. The concentration of phenolic phytochemicals in the outermost layers was significantly higher than the inner edible portion. Similarly, sequential pearling of grains showed gradual decrease in phenolic compound concentration with an increase in the degree of pearling. Evaluation of optimization of different sample preparation parameters showed that particle size, solvent composition, solid-to-solvent ratio, and temperature have significant influence on the yield of phenolic compounds extracted from grains, vegetables, and dietary supplements. The results also showed that most phenolic acids existed in the bound insoluble form in grains. Around 50% of the phenolic acids were recovered in the initial three pearling fine fractions (within ~20% surface removal). Thus, an understanding of the distribution of phytochemicals and optimization of sample preparation procedures are important for accurate analysis and evaluation of their bioactivities.

Biography:

Lisa Stehno-Bittel began her career in healthcare as a physical therapist. With more than 25 years of research experience in the fields of cell biology and diabetes, she has over 60 publications in scientific journals and has received more than $9 million in grant funding for her research. Lisa is on faculty at the University of Kansas Medical Center and serves as President and Founder of Likarda, LLC. She has a BS degree from the University of Kansas, a PhD from the University of Missouri and completed a pharmacology fellowship at the Mayo School of Medicine. Lisa has received numerous awards including the Outstanding Faculty Research Award from the University of Kansas Medical Center and the Jim Baxendale Commercialization Award.

Abstract:

Efficacy and toxicity testing are key to understanding the effects of any nutraceutical compound in the body. Research has shown that in vitro testing done in 3D tissue models is superior to traditional 2D cell culture. We have patented an efficient method of creating and testing 3D cellular models for a variety of tissues including oral health, metabolic function and diabetes, and 12 different types of cancer. For our clients we have compared the nutraceutical product, Triology, to competitive mouth rinses, showing that Triology was less toxic to healthy gum tissue and more efficacious in killing bacteria. Studies of the insulin-producing islet clusters showed that our 3D tissue model outperformed by 2.5 times intact human tissue from donors in predicting which compounds would work best in the body. Likewise, the diabetes drug glybenclamide had a greater response in the 3D tissue model than on native human islets or cells grown in 2D culture. The same trend was noted when testing the effect of a nutraceutical product on miniaturized cancer tumors. The proprietary nutraceutical compound showed better effects in the 3D tissue model. The same was true for standard chemotherapies like paclitaxel, which had no effect on ovarian cancer cells grown in a monolayer, but strongly killed those same cells when they were grown in 3D (60% cell death a 100 M dose). We have tested efficacy and toxicity assays on over 100 different nutraceutical compounds using the 3D tissue model, improving the predictability of the test for in vivo outcomes.

Biography:

Lisa Stehno-Bittel began her career in healthcare as a physical therapist. With more than 25 years of research experience in the fields of cell biology and diabetes, she has over 60 publications in scientific journals and has received more than $9 million in grant funding for her research. Lisa is on faculty at the University of Kansas Medical Center and serves as President and Founder of Likarda, LLC. She has a BS degree from the University of Kansas, a PhD from the University of Missouri and completed a pharmacology fellowship at the Mayo School of Medicine. Lisa has received numerous awards including the Outstanding Faculty Research Award from the University of Kansas Medical Center and the Jim Baxendale Commercialization Award.

Abstract:

Efficacy and toxicity testing are key to understanding the effects of any nutraceutical compound in the body. Research has shown that in vitro testing done in 3D tissue models is superior to traditional 2D cell culture. We have patented an efficient method of creating and testing 3D cellular models for a variety of tissues including oral health, metabolic function and diabetes, and 12 different types of cancer. For our clients we have compared the nutraceutical product, Triology, to competitive mouth rinses, showing that Triology was less toxic to healthy gum tissue and more efficacious in killing bacteria. Studies of the insulin-producing islet clusters showed that our 3D tissue model outperformed by 2.5 times intact human tissue from donors in predicting which compounds would work best in the body. Likewise, the diabetes drug glybenclamide had a greater response in the 3D tissue model than on native human islets or cells grown in 2D culture. The same trend was noted when testing the effect of a nutraceutical product on miniaturized cancer tumors. The proprietary nutraceutical compound showed better effects in the 3D tissue model. The same was true for standard chemotherapies like paclitaxel, which had no effect on ovarian cancer cells grown in a monolayer, but strongly killed those same cells when they were grown in 3D (60% cell death a 100 M dose). We have tested efficacy and toxicity assays on over

Biography:

Alok Bhushan received his PhD degree in Biochemistry in 1981 from Punjab Agricultural University. He did his Post-doctorate from Johns Hopkins University, Medical University of South Carolina and University of Vermont in USA. Following that, he joined Idaho State University in 1998 as a faculty member and during his tenure there, he served as Assistant Professor, Associate Professor, Professor and the Assistant Chair of the Department of Pharmaceutical Sciences. Currently he is Chair and Professor of the Department of Pharmaceutical Sciences at Jefferson School of Pharmacy in Thomas Jefferson University. He has over 70 publications.

Abstract:

Biography:

Prof. Sinerik Ayrapetyan has completed his Ph.D in Cell Biophysics in the Institute of Physiology of Ukraine Academy of Sciences, Kiev. He is the head and coordinator of Research Council of Life Sciences International Postgraduate Educational Center and UNESCO Chair in Life Sciences in Yerevan, Armenia. His current research interest is “Intracellular Signalling System in Norm and Pathology”. On this subject he has published more than 7 international books and 115 papers in refereed journals. He is serving as a member of the board of associate editors for the journals: "Electromagnetic Biology and Medicine" "Journal of International Dental and Medical Research", “ISRN Biophysics” and member of editorial board of the journals: “Advances in Life Sciences", “Bioavailability and Bioequivalence”, “Applied Pharmacy”, “European Journal of Biophysics”, “Biochimica et Biophysica Acta”. He is a member of International Coordination Council of WHO and number of professional international societies.

Abstract:

Age-induced medical disorders are modern problems in medicine and have become a focal point for public health concern due to the aging of the world population. The main barrier for solving this problem is, in the literature available for us, the absence of a reliable, universal biomarker for detection of the functional state of the whole organism though there are different methods for detection of the functional state of individual organs. We believe that metabolic controlling of cell hydration could serve as a universal biomarker for estimation of the effect of different chemical and physical factors, including food and drinking water, on the functional state of the organism. By our previous study it was shown that cell pathology, including aging, leads to the dysfunction of Na+/K+-ATPase α3 isoform-dependent intracellular signaling system controlling cell hydration. Therefore, we suggest that that activation of α3 isoform-dependent cell hydration could serve as a marker for estimation of bioavailability of food and drinking water. For this purpose, elaboration of a new non-invasive device with corresponding software for detection of muscle hydration based on frequency-dependent characteristics of muscle impedance is suggested. The experimental data that prove our suggestion will be demonstrated in the lecture.