Advances in Natural Medicines, Nutraceuticals & Neurocognition

Selenium is an essential micronutrient, whose main function is as an antioxidant through its incorporation into proteins to alleviate oxidative stress in cells. This study examined the effects of selenium combined with protein through the selenitealgae-oyster pathway in the pearl oyster Pinctada martensii. The study was designed to explore the possible role of selenoprotein against oxidative damage induced by hydrogen peroxide (H2O2) of cardiomyocytes and its potential mechanisms. The results showed that the combination rate between selenium and protein improved significantly via the enrichment effect. Furthermore, selenoprotein can protect cardiomyocytes that are oxidatively injured by H2O2. The beneficial effects of selenoprotein were likely mediated by an inhibition of Malondialdehyde (MDA) and an increase in the activity of Superoxide Dismutase (SOD) and Glutathione peroxidase (GSH-Px), A maintenance of the mitochondrial membrane potential and a reduction of intracellular Ca2+ overload.