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Seung-Kwon Myung

Seung-Kwon Myung

National Cancer Center, South Korea

Title: Efficacy Of Vitamin And Antioxidant Supplements In Prevention Of Bladder Cancer: Meta Analysis Of Randomized Controlled Trials

Biography

Biography: Seung-Kwon Myung

Abstract

This meta-analysis aimed to investigate the efficacy of vitamin and antioxidant supplements in the prevention of bladder cancer as reported by randomized controlled trials (RCTs). We searched PubMed, EMBASE and the Cochrane Library in April 2015. Two of the authors independently reviewed and selected eligible RCTs, based on pre-determined selection criteria. Out of 180 articles searched from three databases and relevant bibliographies, 14 RCTs were included in the final analysis. In a fixed effect meta-analysis, there was no efficacy of vitamin and antioxidant supplements in the prevention of bladder cancer (relative risk (RR), 1.03; 95% confidence interval (CI), 0.91-1.16; I2=43.4%). Overall, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone was marginally increased the risk of bladder cancer (RR, 1.44; 95% CI, 1.00-2.09; I2=0.0%; n=3). The current meta-analysis of RCTs found that there was no clinical evidence to support the efficacy of vitamin and antioxidant supplements in the prevention of bladder cancer.