Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 14th International Congress on Advances in Natural Medicines, Nutraceuticals & Neurocognition London, UK.

Day 2 :

Keynote Forum

Enitan Ogundipe

Imperial College London, UK

Keynote: Maternal LCPUFA status, infant first meconium and newborn MRI brain volumetrics

Time : 10:00-10:45

Nutraceuticals 2018 International Conference Keynote Speaker Enitan Ogundipe photo
Biography:

Enitan Ogundipe is a Consultant in Neonatal Pediatrics at Chelsea & Westminster Hospital, London, UK (Dec 2000 – date); Honorary Senior Lecturer in Child Health, Division of Medicine, Imperial College London, UK and also Lead of Specialist Training and the Current Neonatal College Tutor. Their unit is a specialist perinatal tertiary center and designated unit in the sector for neonatal surgery. Her area of interest lies in research and clinical care aimed at enhancing the brain development of high risk babies and is focused on factors such as nutrition especially essential lipids of the mother and newborn infants in relation to their developmental and health outcomesnutritional intervention in the pre-conception period, pregnancy, newborn period in baby and assess the effect on brain development and disorders in infants.

Abstract:

The neuromediators epinephrine (adrenaline), dopamine and serotonin stimulate at a concentration of 1M the growth of some strains of Lactococcus lactis subsp. lactis, a popular probiotic species that is widely used in functional food items. The growth of the strain L. lactis subsp. lactis 194c is threefold accelerated by all the three neuromediators. Epinephrine and serotonin produced no statistically significant effect on the growth of the other strains tested (K-205,   and F-116). Dopamine increased the growth of K-205 and 729 but not of the fusion strain F-116. It is known that neuromediators accumulate in the bloodstream and in the intestinal lumen of stressed individuals, especially if the stress is accompanied by local intestinal inflammation. Therefore, it is in a stressed organism that the tested probiotic strains are expected to grow particularly fast. This fact is of indesputable medical interest because probiotics including L. lactis subsp. lactis help the organism cope with stress. Using HPLC with an amperometric detector, it was established that strains K-205 and F-116 produce submicromolar amounts of their own dopamine and of its precursor, 2,3-Dihydroxyphenylalanine (DOPA). DOPA passes the gut–blood and the blood–brain barriers. Therefore, such DOPA-producing probiotic cultures could be applied, in the form of drugs or fermented dairy products for the purpose of improving the physical and mental health state of patients with neurological disorders including Parkinson’s disease.

Nutraceuticals 2018 International Conference Keynote Speaker Elizabeth Jeffery photo
Biography:

Dr. Jeffery completed her PhD in biochemistry at the Royal Free Hospital School of Medicine, University of London, UK in 1972. She joined the University of Illinois as faculty in 1983 and became a full professor of Nutritional Pharmacology in both the Department of Food Science and Human Nutrition and in the Medical School (Pharmacology faculty) in 2000. She has over 150 publications, many in the area of broccoli and health. She received the American Society for Horticultural Science’s paper of the year in 2002 and the American Society of Nutrition’s Dannon Institute award for mentorship in 2016. As Professor Emerita, she continues to have students, an active laboratory and reviews manuscripts for many journals.

Abstract:

Broccoli is known to contain the health promoting compound Sulforaphane (SF). Most consumers prefer the flavor of cooked,
rather than raw broccoli. However, cooked broccoli has been suggested to provide essentially no health benefits compared to raw broccoli. This is because the plant enzyme myrosinase, that releases SF from its inactive precursor glucoraphanin when broccoli is chewed, is in large part destroyed by cooking. SF is known to activate nuclear factor erythroid 2-related factor 2 (Nrf2), the critical trigger to increasing antioxidant defense and detoxification pathways. Here we report that the microbiome has the ability to release SF from its inactive precursor, particularly because frequent cooked broccoli ingestion alters the microbiome in a positive manner in mice and human subjects. We find that following broccoli ingestion, sufficient SF is released into the colon by the microbiome, whether the broccoli is cooked or raw to act locally to activate Nrf2 and prevent colitis. The health impact of acute and chronic inflammation and the effect of the broccoli component SF on inflammation will be discussed.

Break: Networking & Refreshments 11:30-11:50 @ Breakout Area
Nutraceuticals 2018 International Conference Keynote Speaker Augustine Isikhuemen Omoigberale photo
Biography:

Augustine Isikhuemen Omoigberale is a Professor of Paediatrics and Child Health (Neonatology), Department of Child Health, School of Medicine, College of Medical Sciences, University of Benin and Honorary Consultant at University of Benin Teaching Hospital, Benin city, Nigeria. He is a graduate of the University of Benin, College of Medicine and a Fellow of the West African College of Physicians (Paediatrics) since late eighties. He is currently the President of Paediatric Association of Nigeria (PAN). He has attended many training courses both in Nigeria and outside Nigeria, University of Maryland, Baltimore, Baylor College of Medicine, Houston, Texas USA, to mention just a few. He teaches Neonatology, Breastfeeding and Infant Feeding, Gastroenterology, General Paediatrics Infection, Paediatrics HIV and AIDS, Management of Paediatrics HIV exposed Infected and Affected Infants and Children, Prevention of Mother to Child Transmission of HIV, HIV/Infant Feeding options. His research areas focus mainly on General Paediatrics, Breastfeeding and Gastroenterology, Specifically Paediatrics HIV/AIDS, Neonatology and related issues. He has more than 65 publications in both local and international Journal articles, conference papers, seminars presentations, text books and has supervised over 20 dissertations leading to the award of the Fellowship in Paediatrics of both West African College of Physicians and National Postgraduate Medical College of Nigeria

Abstract:

Nutrition is an important aspect of child health. Under-nutrition puts children at greater risk of dying from common infectiousdiseases, increases the frequency and severity of such diseases and contributes to delayed recovery from illnesses. In addition, the interaction between under-nutrition and infection can create a potentially lethal cycle of worsening illness and deterioratingnutritional status. In terms of overall progress towards the sustainable development goals, the Sub-Saharan Africa is far behind all other regions in achieving the goal of over-coming hunger. Under-nutrition causes nearly three million children death annually and that poor nutrition in the first 1000 days of any child can lead to irreversible stunted growth and impaired cognitive ability. The most affected age is infancy due to the critical period of brain growth and development. Breastfeeding is an important component of child survival strategy. However as readily available breast milk is, the breast feeding rate in sub Saharan Africa and Nigeria is still low. This is largely due to ignorance of true benefits of breastfeeding to baby, mother and the community, maternal quest for white collar jobs and poor government policies. This key note address will tend to highlight breast feeding as the true foundation of infant nutrition and as well highlight the benefits, challenges and proper solutions facing optimal breast feeding.

Keynote Forum

Maria Livia Ognean

Lucian Blaga University of Sibiu, Romania

Keynote: Factors associated with exclusive formula feeding in late preterm infants
Nutraceuticals 2018 International Conference Keynote Speaker Maria Livia Ognean photo
Biography:

Maria Livia Ognean is an Assistant Professor at Faculty of Medicine, University Lucian Blaga, Sibiu. She completed her MD from the University of Medicine and Pharmacy Tg. Mures, PhD from University of Medicine and Pharmacy Cluj Napoca, Senior Neonatologist, Chief of Neonatology Department I, Clinical County Emergency Hospital Sibiu, Romania. She is working as Associate Professor at University Lucian Blaga Sibiu since 2006. She is a member of national and international neonatology and perinatology societies, member of the Executive Committee of UENPS, Secretary of the Romanian Association of Neonatology during 2010-2017, Former Scientific Secretary of the Romanian journal Neonatologia,, published over 140 papers in national and international journals.

Abstract:

Introduction: Late preterm delivery rate is continuously increasing worldwide due to multiple factors: Increased rate of multiple pregnancies, increased incidence of pregnancies associated with health conditions since advanced maternal age is also rising, increased preference of both professionals and mothers for elective induced labor and cesarean section, avoidance of obstetric malpractice litigation, etc. Experts are talking now about the paradox of breastfeeding association with increased morbidity in late preterm infants (LPI) searching feeding guidelines for infants to improve their short and long term outcome.
 
Aim: The authors evaluated which factors are associated with exclusive formula feeding in late preterm infants.
 
Material & Methods: The retrospective study included LPI (340-366 weeks gestation) born between January 1, 2013 and December
31, 2016 in the maternity of the Clinical County Emergency Hospital Sibiu, a level III regional unit. The unit protocol for breastfeeding follows the 10 steps recommended by the Baby Friendly Hospital initiative. Infants not fed at discharge were excluded. Maternal and neonatal characteristics, epidemiological and clinical data were extracted from neonatal charts and comparatively analyzed between exclusively breastfed and formula fed LPI. Statistical analysis was performed using SPSS for Windows 10.0 p was considered statistically significant if <0.05 (CI 95%).
 
Results: 489 LPI were admitted in our unit during the four year study period, 103 exclusively breastfed (21.2%), 36 exclusively fed with formula (7.4%) and 347 with mixed feedings (71.4%). 3 infants were submitted without feedings to pediatric surgery. As compared to exclusively breastfed LPI, formula fed infants had significantly lower birth weight (p<0.001), gestational age (p 0.018), Apgar score at 1 minute (<0.001), increased need for birth resuscitation (27.8% vs. 11.7%, p 0.022; OR 1.42), increased rate of cesarean section delivery (44.4% vs. 24.3%, p 0.021; OR 1.30), maternal-fetal infection (25% vs. 8.7%, p 0.012; OR 1.55), admission rate to neonatal intensive care unit (58.3% vs. 30.1%, p 0.003; OR 1.39) and an increased length of hospitalization (26.6±23.0 days vs. 11.4±8.6 days; p<0.001). Mothers of the formula fed LPI had increased age (p>0.05), number of gestations and parity (p<0.005),
reduced educational level (p<0.0001) and lack of prenatal care (47.2% vs. 19.4%, p 0.001) compared to mothers that successfully
breastfed their infants at discharge. A very low rate of exclusive breastfeeding was noted in LPI twins (11.7%) and those born from
pregnancies obtained with assisted reproductive techniques (ART) (1.%). An increased rate of exclusive breastfeeding was noted in 2016 compared to previous years of study (up to 41.7% of LPI).
 
Conclusion: Unfortunately, LPI with the most complicated perinatal course are not benefiting from breast milk and breastfeeding. Interventions for improving breastfeeding rates must be directed towards multiparous women with low level of education. Efforts must be done to improve the prenatal care in this category of pregnant women. Also, twins and infants born from ART pregnancies are also identified as at risk categories as regards successful breastfeeding.

Break: Lunch Break 13:20-14:20 @ RBG