Day 1 :
- Keynote Speech
Session Introduction
Norihisa Kato
Hiroshima University, Japan
Title: The role of vitamin B6 in health and diseases
Biography:
Norihisa Kato has completed his PhD (1980) from Nagoya University, Japan. Currently, he is a professor in Laboratory of Molecular Nutrition, Graduate School of Biosphere Science, Hiroshima University. His research interests are in elucidation of anti-disease food factors and the molecular mechanisms. He is a expert editor of Journal of Nutritional Science and Vitaminology, and has published more than 200 papers. He was given the Award for Excellence in Research Japan Society of Nutrition and Food Science (2012).
Abstract:
Although vitamin B6 is widely distributed in various foods, there is evidence that many adults are not obtaining adequate amounts of this nutrient from their diets, implying that the nutritional importance of vitamin B6 is under-recognized. In 2001, our group provided the first evidence for the anti-colon tumor effect of dietary supplemental vitamin B6 in mice received azoxymethane. Since then, a number of epidemiological studies have suggested an inverse association between vitamin B6 status and the risk of cancers. Furthermore, there is accumulating epidemiological evidence suggesting anti-cardiovascular and anti-inflammation effects of vitamin B6. Studies in our laboratory have indicated anti-inflammatory, anti-proliferative, anti-angiogenesis, and anti-oxidant effects of vitamin B6 in animals and cell culture studies. Recent our studies have revealed novel anti-inflammatory activities of vitamin B6, suggesting potential utility of vitamin B6 in preventing NLRP3 inflammasome-driven inflammatory diseases. We further found the elevation of carnosine and anserine (anti-inhibitory, anti-oxidant and ergogenic dipeptides) in heart and skeletal muscles of rats by dietary supplemental vitamin B6. These findings explain why vitamin B6 has important role in the anti-disease functions and health. In this lecture, I will present recent progress in the studies on these functions of vitamin B6.
Nicolas Wiernsperger
Lyon University, France
Title: Mechanisms common to chronic diseases may be the best targets for nutraceutical approaches
Biography:
Nicolas Wiernsperger has completed his PhD from Basle University, Switzerland. He was a Researcher at Novartis (Basle, Switzerland) and later a Research Director at Lipha/Merck KgA in Lyon, where he was chairing the international pharmacological development as well as a public/private research unit at Lyon University. He is an internationally recognized specialist in pathophysiology and pharmacology of microcirculation, metabolic syndrome and diabetes. He has published more than 140 papers in reputed journals, Editor of 2 books and has been serving as an Editorial Board Member.
Abstract:
Chronic degenerative diseases characterizing aging human beings share some common key mechanistic defects which, according probably to epigenetic and environmental factors, direct progressions towards the one or other pathology. One such key step is cellular resistance to insulin. Recent research has identified insulin resistance as a defect found in metabolic and vascular processes going far beyond the “classical” view of insulin’s biological effects on glucose metabolism. As a ubiquitous phenomenon showing an extremely high prevalence in the population, insulin resistance is now increasingly seen as an early occurring cellular disturbance affecting most various diseases. These observations then point to the likelihood of common origins of insulin resistance. Although multiple defects in insulin cellular action have been unraveled over the two last decades, it appears that one common denominator is chronic low grade inflammation. While the latter it may have different causes, mechanistic analysis of insulin resistance microvascular and metabolic disturbances shows that the chronic, even moderate augmentation of inflammatory substances (largely cytokines) is key to its genesis. The author will give a complete overview of these commonalities, which may explain the long term development of the main diseases affecting worldwide aging population. Since these defects are both mild and very lasting, they may be best suited as targets for nutraceutic therapy.
KP Mohana Kumar
Director & Professor, Mahatma Gandhi University, Kerala, Inida
Title: Synergistic actions of nutraceuticals with drugs: Neuro-nutraceuticals & CNS drugs
Time : 11:00-11:35
Biography:
Mohanakumar KP is the Director of Inter University Centre for Biomedical Research & Super Specialty Hospital, a Govt of Kerala autonomous institution with Mahatma Gandhi University, Kottayam, Kerala, India. He graduated from Saurashtra University with a Master’s degree in Chemical Neuroanatomy and PhD in Neurochemistry. He was Chief Scientist at CSIR-Indian Institute of Chemical Biology, Kolkata, where he has established a laboratory on neurodegenerative diseases, with special reference to Parkinson's disease, in relation to pathogenesis, progression of the disease and its treatment. His cybrids laboratory facility is recognized for his interest in mitochondrial involvement in neurodegenerative diseases. He has more than 125 peer reviewed publications, and guided 30 PhD students in the field of Neuropharmacology, and more than a 100 postgraduates in Medicine, Pharmacology, Biotechnology, Biochemistry and other biomedical discipline. A fellow of the National Academy of Sciences, India; West Bengal Academy of Science & Technology and Indian Academy of Neurosciences, he received National Bioscientist Award from DBT, Govt. of India and ICMR, Govt. of India Young Scientist Prize. He is a Professor of Biological Sciences of AcSIR, India and served as Professor of TWAS-UNESCO and IISER, Thiruvananthapuram. He serves as editorial member of J Neurochem, Neurochem Int, Neurochem Res, Neurosci Med, Anat Cell Biol, etc.
Abstract:
Many molecules contained in our daily intake of food act as nutraceuticals, and its concentration, time of intake and duration for which it is available in the body are critical to influence human health. Diet-rich in nutraceuticals or supplementation of identified nutraceuticals in the diet along with yoga, exercise, increased outdoor activities and maintenance of a reasonably balanced body weight will maximise a healthy mind and body with reduced disease risk. It is amazing how health prospects are bettered by simply changing food habits, increasing availability of nutraceuticals in the diet either with nutraceutical supplements or introducing nutraceutical rich diet or increasing fermented foods. A healthy mind is integral to a healthy body, and considering genetic predisposition of an individual, nutraceuticals will act as substrates of biochemical reaction, co-factors or inhibitors of enzymes, absorbents that binds to undesirable molecules in the GI tract, scavengers of toxic molecules and free radicals, enhance of absorption of micronutrients, help to balance micro-biome of the gut, and maintain a healthy brain-gut axis, resulting in variable reversal of traumatic, inflammatory, toxic, immune and vascular damages to nervous tissue. However, chronic neurological diseases, which results from many causes and risk factors such as genetic predisposition, advanced unhealthy lifestyle, exposure to toxins/toxic chemicals, infections, immuno-deficiencies, adverse environment causing epigenetic mechanisms going haywire, and co-morbidities from diabetes, and cardiovascular complications cannot be cured or addressed successfully with diets, nutritive supplements, or herbals or phytochemicals, but should be treated with prescription drugs. The nutraceuticals while interacting with prescription drugs, do they synergize with modern drug molecules to provide better health prospects or do they complicate the drug effects to worsen the side effects situations over long-term is a major issue? This is important since more than 10% of all apparent decline in neurological disorders, such as cognition, sensory and motor functions, GI track immobility, etc are resulting from iatrogenic effects due to the overuse of OTC or prescription drugs. Neuro-nutraceuticals are the new horizons that might just help to address this issue. Evidences are getting accumulated to support the notion that even the primary drug effects could be synergized by neuro-nutraceuticals, solving the issues of tolerance and toxicity due to higher drug doses. Neuro-nutraceuticals might work through specific messenger molecules that cross over from the regulation of GI tract and immune functions to neuronal function, and vice versa. It has become a way for neurologists to treat CNS diseases and neuropsychaitric conditions (eg. hepatic encephalopathy, inflammatory disease, obsessive compulsice disorders,attention deficit hyperactive disorders, depression, several neurodegenerative diseases, etc.) with 'functional foods', and this has turned its focus on botanicals and/or nutritional phytochemicals, essential fatty acids or its natural sources, biologicals such as phosphatidylserine, acetyl-l-carnitine, vinpocetine, vitamins, glutathione, α-lipoic acid, n-acetyl-cysteine, bioflavonoids, flavone glycosides, phytooestrogens, coenzyme Q10, s-adenosyl methionine, etc. Not but the least, habit of tea or coffee or wine drinking is also shown to synergize with neurological drugs to provide better therapeutic outcome, and in significant cases it has helped to reduce the dosage of prescription drugs.
- Symposium: Agri by-products to nutraceuticals: Prevention of Lifestyle Diseases
Session Introduction
Chandan Prasad
Texas Woman’s University, USA
Title: Agri-byproducts, an unexplored resource for health promotion
Time : 11:35-12:00
Biography:
Chandan Prasad graduated from Louisiana State University in 1970 with a Ph.D. in microbiology/biochemistry. After 8 years at the NIH in Bethesda, Maryland as Fogerty fellow and senior staff fellow, he returned to New Orleans to join the faculty of LSU School of Medicine. He served LSU Health Sciences Center as professor (medicine and neuroscience), Director of Obesity Research Program, and vice chairman (research) in the Department of Medicine until 2006. He was the first chair of the laboratory of Nutrition and Brain at the Pennington Biomedical Research Center from 1991-1993 under directorship of Prof. George Bray MD. He joined Texas Woman’s University as Professor & Chair of the Department of Nutrition and served in this capacity until 2012. He also served TWU as Assistant Provost for Research Promotion from 2012 to 2014. Currently, he is Professor of Nutrition and Food Sciences at the Texas Woman's University and Professor (Emeritus) of Medicine (Endocrinology) at the LSU Health Sciences Center- New Orleans, LA. The current focus of Dr. Prasad’s research is on inflammation and the role of dietary supplements in obesity, diabetes, and heart diseases. He has authored more than 200 papers in the area off appetite regulation, obesity, and nutrition. He holds four U.S. and international patents for treatment of obesity and alcoholism. He is Founding Editor of Nutritional Neuroscience, series editor for Nutrition, Brain, and Behavior, Editor-in-Chief of Current Topics in Nutraceutical Research and Member of the Board of the International Society of Nutrigenetics/Nutrigenomics .
Abstract:
Agri-byproducts result from agricultural activities such as cultivation of rice, wheat, barley, corn, sugarcane, banana and other crops as well as food processing and manufacturing. These byproducts are rich source of arabinogalactans, cellulose, hemicellulose and lignin and a variety of other compounds. While some of these byproducts have used for production of fibers, ethanol and chemicals such as furfural, the most go as animal feed, compost or waste. Significant progress in analytical/processing chemistry and biotechnology methods in the last decades has opened the possibility of developing new uses of agri-byproducts commonly referred to as agri-wastes. The cellulosic byproducts are well suited to be converted into high value nutraceuticals (beta-Glucans, Resistant Starch, Glucomannan, Chitosans, Arabinoxylans) capable of reducing inflammation, enhancing immune response and arresting cell growth of cancer cells. This presentation will summarize existing data and suggest future directions on identification, characterization, derivatization, biologic testing and function of agricultural byproducts as possible nutraceuticals for human use.
Zhao-Jun Wei
Hefei University of Technology, China
Title: The nutraceutical properties of polysaccharides sequential extracted from peony seed dreg
Biography:
Zhaojun Wei has received his BS from Anhui Agricultural University (1993), MS from Chinese Academy of Agricultural Sciences (2001) and PhD from University of Science and Technology of China (2005). Currently, he is the distinguished Professor and Deputy Dean of School of Biotechnology and Food Engineering at Hefei University of Technology (HFUT). He also serves as the Chairman of the Agricultural and forestry specialty food processing industry technological innovation strategic alliance of Anhui province, Chairman of the Hefei Society for Nutrition, and a Member of the Chinese Society of Biochemistry and Molecular of Agriculture. His research focuses on the processing and function of nutraceuticals from the byproducts of Agriculture and forestry, e.g., DNJ from mulberry, Pectin from okra, polysaccharides from peony seed dreg and others.
Abstract:
Peony seed dreg, a byproduct of oil processing, is rich in many nutrients. However, this is always used as animal fodder and fertilizer. My laboratory has explored the possible use of nutrient-rich peony seed dreg as a functional food. To this end, Peony seed dreg polysaccharides (PSDP) were sequentially extracted using hot buffer (HBSS), chelating agent (CHSS) and dilute alkaline (DASS) followed by concentrated alkaline (CASS). The nutraceutical properties of the various polysaccharides fractions were investigated. The four PSDPs possessed simple composition and showed the characteristic absorptions for polysaccharides at 3600-3200 cm-1 and 3000-2800 cm-1. The functional group of four PSDPs displayed some slight differences. The results of melting point and enthalpy of four samples confirmed a good thermal stability. The emulsifying activity and emulsifying stability of four PSDPs exhibited dose-dependent response, HBSS with the highest emulsifying activity and CHSS with the longest emulsifying stability. Comparison among the antioxidant activities of four PSDPs, CASS showed highest abilities in the DPPH radical scavenging activity, reducing power and ABTS radical scavenging activity, HBSS exhibited the highest hydroxyl radical scavenging activity and CHSS displayed the higher chelating ability on ferrous ions than others. At a liquid-solid ratio less than 2.5% w/w in aqueous solution, the polysaccharides extracted from peony seed presented non-Newtonian shear thinning behavior and could be well described by the Cross model. The peony seed polysaccharides showed predominantly viscous responses (G’
Lin shaoling
Fujian Agriculture and Forestry University, China
Title: Sensory and nutritional properties of chinese olive pumace based high fiber biscuit
Biography:
Shaoling Lin has completed her PhD from The Chinese University of Hong Kong.
Abstract:
Consumer interest in healthy eating is shifting towards the potential health benefits of specific foods and food ingredients. Unconventional ingredients combined with usual bakery flour yields better acceptable, healthy and nutritious bakery products. The present study aims to evaluate the sensory and nutritional properties of Chinese olive pumace based high fiber biscuit. The high fiber biscuit was formulated using Chinese olive pumace powder (15%), wheat (100 g), sugar powder (33%) and spices after repeated trials and the recipe was standardized. When subjected to sensory evaluation, the newly formulated high fiber biscuit derived a score of 4.5±0.51, out of a maximum score of 5, for its overall acceptability, indicating the biscuit was well accepted. The results of the nutritional quality and cost of the newly formulated high fiber biscuit showed that it contains the 10.20 g fiber, 1454 Kcal calories and 18.30 g fat in 100 g biscuit. Furthermore, the glycemic index (GI) results indicated that GI of olive high fiber biscuits was 63.68 which was significantly lower than the control one with the GI value of 76.66. Besides, the physical and chemical indicators as well as the microbiological indicators were also up to the Chinese national standards (GB/T20980-2007 and GB7100-2003). Hence, the study proved that the newly formulated olive pumace powder based biscuit is well acceptable based on its sensory properties and fiber rich nutritional quality.
Ying Ma
Harbin Institute of Technology, China
Title: Binding characteristics of curcumin to β-Lactoglobulin
Time : 14:00-14:25
Biography:
Professor Ying Ma has completed her PhD from Northeast Agricultural University and postdoctoral studies from Chinese Agricultural University. Now Dr. Ma, as a professor and doctor student’s supervisor, works in institute of food science and engineering of Harbin Institute Technology. She also is associate editor of an international journal《Dairy Science and Technology》(formerly le lait). Her research area mainly focuses on the food chemistry, food safety，the modifications of starch and plant protein, and bioprocess of agricultural food. As a coordinator, she jointed several national and local research projects. More than 248 peer- reviewed research papers were published in primary journals. She owned 21 authorized patents and 22 edited Chinese books and 5 peer-reviewed English books.chapters.
Abstract:
Curcumin (CCM) is a phenolic compound and has been shown to exhibit many bioactivities, but it is extremely limited in its application due to its insolubility in water. β-Lactoglobulin (β-Lg) is a major whey protein and has an ability to bind hydrophobic molecules because of its hydrophobic core. In this experiments, the binding of CCM to β-Lg was investigated. The results showed that binding CCM to β-Lg leads to a partial change in protein structure. CCM was bound respectively to two different sites of protein at pH 6.0 and pH 7.0 via hydrophobic interaction. CCM-β-Lg complex was formed by one molecule of protein combining with one molecule of CCM. The solubility of CCM was increased by 15954-fold through the complex. The β-Lg -CCM complex and CCM in complex had a good stability in the pH range of 2 to 8. The results of antioxidant experiments showed that the ABTS and hydroxyl radical scavenging capacity of CCM was reduced by binding with β- Lg, but the total reducing ability of CCM was improved.
Jiankang Liu
Xi'an Jiaotong University, China
Title: Targeting mitochondria for preventing and treating metabolic syndrome with natural compounds from food and nutrition
Time : 14:25-14:50
Biography:
Jiankang Liu has received his BS from Xi’an Jiaotong University and PhD of Medical Science from Okayama University School of Medicine, Japan. He has completed Post doctorate training in Dr. Bruce Ames Laboratory at University of California, Berkeley and worked as a Faculty at University of California at Berkeley, Children Hospital Oakland Research Institute, University of California at Irvine, University of Kentucky College of Medicine and Shanghai Institute for Nutritional Science, Chinese Academy of Sciences. Currently, he is a Professor and the Dean of Xi’an Jiaotong University School of Life Science and Technology and an Adjunct Professor of the School of Pharmacy, University of Southern California. His research interests include molecular and cellular mechanisms of aging, stress and age/stress associated degenerative diseases with a focus on nutritional regulation of mitochondrial metabolism.
Abstract:
Insulin resistance is an important feature of metabolic syndrome such as type-2 diabetes, obesity and cardiovascular disease. The underlying mechanisms of insulin resistance are still unclear. Mitochondrial dysfunction, including disorders of mitochondrial biogenesis and mitophagy and imbalance of redox system has been suggested to be involved in insulin resistance. Increasing evidence suggests that targeting mitochondria to protect mitochondrial function could prevent and ameliorate various diseases associated with mitochondrial dysfunction forming a unique field, i.e., mitochondrial medicine. In this presentation, I have summarized our recent studies with nutrients to target mitochondria by stimulating mitochondrial homeostasis to improve mitochondrial function and regulate redox balance for preventing and ameliorating metabolic syndrome. We have focused on natural compounds from food and nutrition including olive, bitter gourd and pomegranate to regulate mitochondrial biogenesis and degradation in cellular systems and in animal models. The in vitro and in vivo studies on the effects and mechanisms of mitochondrial targeting nutrients or their combinations may help us to understand the importance and mechanisms of mitochondrial remodeling and to develop mitochondria-targeting agents for preventing and treating obesity, diabetes and cardiovascular disease.
Rolando L. Maddela
Senior Director of Clinical Research and Scientific Affairs, Mannatech Incorporated, USA
Title: Arabinogalactan and other polysaccharides in health
Time : 14:50-15:15
Biography:
Dr. Maddela is the Senior Director of Clinical Research and Scientific Affairs of Mannatech, Incorporated located in Coppell, United States. He oversees the administration of product clinical trials and the product Safety Monitoring Program. Before joining Mannatech in 2005, he was for 20 years involved with several major public health programs in the Asia Pacific Region working with the academe, government, non-profit and international organizations. He earned a Bachelor of Science in Public Health from the College of Public Health, University of the Philippines, Manila and his MD degree from the University of the East Ramon Magsaysay Memorial Medical Center (UERMMMC), Philippines. In 1990 he obtained his Master of Public Health (MPH) degree with Distinction from the Braun School of Public Health and Community Medicine at the Hebrew University in Jerusalem, Israel. While in the United States, Dr. Maddela has completed several coursework on Public Health, Clinical Research, Data and Project Management, and Leadership in other US academic and professional institutions. He is a Certified Clinical Research Professional (CCRP) and has directed or monitored to successful completion several preclinical and clinical studies conducted in collaboration with academic or other research organizations.
Abstract:
Exogenous polysaccharides play many roles in various biological processes including health promotion by enhancing immune function. For example polysaccharide products derived from the larch tree (Larix spp.), brown algae (Undaria pinnatifida) and Aloe vera (Aloe barbadensis Mill) have been studied alone or in combination for immune function enhancement. Since these polysaccharides are generally considered innocuous, health care providers are very interested in their efficacy and safety following oral intake. The recent clinical studies, although still few compared to in vitro and animal studies, have so far demonstrated that oral intake of arabinogalactans, fucoidans and mannans can modulate immune response in humans. Furthermore, these polysaccharides are well tolerated. Although there is increasing awareness of oral polysaccharides’ multiple roles in health including their immunomodulatory actions, further research is warranted to help understand the spectrum of other health effects and to help explain the mechanisms underlying some of the observed health benefits.
Chandan Prasad
Texas Woman's University, USA
Title: Management of hyperuricemia in prepubertal children: Is there a role for functional fibers?
Time : 15:15-15:40
Biography:
Chandan Prasad graduated from Louisiana State University in 1970 with a Ph.D. in microbiology/biochemistry. After 8 years at the NIH in Bethesda, Maryland as Fogerty fellow and senior staff fellow, he returned to New Orleans to join the faculty of LSU School of Medicine. He served LSU Health Sciences Center as professor (medicine and neuroscience), Director of Obesity Research Program, and vice chairman (research) in the Department of Medicine until 2006. He was the first chair of the laboratory of Nutrition and Brain at the Pennington Biomedical Research Center from 1991-1993 under directorship of Prof. George Bray MD. He joined Texas Woman’s University as Professor & Chair of the Department of Nutrition and served in this capacity until 2012. He also served TWU as Assistant Provost for Research Promotion from 2012 to 2014. Currently, he is Professor of Nutrition and Food Sciences at the Texas Woman's University and Professor (Emeritus) of Medicine (Endocrinology) at the LSU Health Sciences Center- New Orleans, LA. The current focus of Dr. Prasad’s research is on inflammation and the role of dietary supplements in obesity, diabetes, and heart diseases. He has authored more than 200 papers in the area off appetite regulation, obesity, and nutrition. He holds four U.S. and international patents for treatment of obesity and alcoholism. He is Founding Editor of Nutritional Neuroscience, series editor for Nutrition, Brain, and Behavior, Editor-in-Chief of Current Topics in Nutraceutical Research and Member of the Board of the International Society of Nutrigenetics/Nutrigenomics
Abstract:
Although uric acid was first identified some two centuries ago, newer pathophysiologic aspects of hyperuricemia continue to emerge. For years, hyperuricemia has been thought to be exclusively associated with Gout, but it has now been associated with a number of metabolic and hemodynamic abnormalities in adults. More recently, we have examined association between hyperuricemia and components of metabolic syndrome (dyslipidemia, obesity, insulin resistance, and elevated blood pressure) in prepubertal obese school children from underserved population of Nuevo Leon, Mexico. To our surprise, we observed that compared to normal weight children, children in the obese group had significantly greater waist circumference, higher systolic and diastolic blood pressure, elevated fasting insulin and insulin resistance (IR), higher triglycerides, serum uric acid (sUA) and lower HDL-cholesterol. Among the obese children, 33% had characteristics of MetS and 57% of these children had sUA between 5.1-7.1 mg/dl. sUA was positively associated with IR and dyslipidemia. We cannot be certain at this time whether hyperuricemia is the cause or effect in the sequelae of the disease process. However, management of hyperuricemia in young children will be problematic since pharmacologic agents used to treat the condition are largely for adults with no experience with children and plethora of side effects. Therefore, I would like to summarize available data exploring the possibility of managing hyperuricemia in children with functional fibers.
Norihisa Kato
Hiroshima University, Japan
Title: Aspergillus derived protease as a novel bifidogenic factor
Biography:
Norihisa Kato has completed his PhD (1980) from Nagoya University, Japan. Currently, he is a professor in Laboratory of Molecular Nutrition, Graduate School of Biosphere Science, Hiroshima University. His research interests are in elucidation of anti-disease food factors and the molecular mechanisms. He is a expert editor of Journal of Nutritional Science and Vitaminology, and has published more than 200 papers. He was given the Award for Excellence in Research Japan Society of Nutrition and Food Science (2012).
Abstract:
Traditionally, Aspergillus species have been widely used for the production of a variety of fermented Japanese foods including, miso, soy sauce, sake, and sake lees. However, there is limited study on the application of Aspergillus species for the production of functional foods beneficial for health. In a recent animal study, we observed a marked elevation in the colon Bifidobacterium and organic acids in rats fed Aspergillus-fermented burdock compared to burdock powder (Okazaki et al. Biosci Biotechnol Biochem 77: 53, 2013). Similar observations were made in rats fed with water-soluble fraction from the fermented burdock and other Aspergillus-fermented foods such as malted rice and multi-grain malt. Since the water-soluble fraction from the fermented burdock contained substantial amount of extracellular proteases derived from Aspergillus, we postulated that bifidogenic effects might be associated with Aspergillus-derived proteases. To test hypothesis, rats were fed a diet containing 0.1% protease A ‘Amano’ SD (Aspergillus oryza，Amano Enzyme Inc.) (Amano protease) and number of Bifidobacterium in colon was measured. The results showed a marked elevation in colon Bifidobacterium population (Yang et al. Biomed Rep 3: 715, 2015). Since the Amano protease preparation is a mixture of several proteases, we set out to identify the active protease responsible for the bifidogenic effect. Our results show an acid protease derived from Aspergillus oryzae to exhibit a potent bifidogenic effect that was lost when protease was inactivated. A dietary addition of 0.0384% acid protease was comparable to 5 to 10% of prebiotics (e.g., oligosaccharides and dietary fibers) in raising colon Bifidobacterium population. In conclusion, our findings provide an insight into novel applications of an acid protease derived from Aspergillus as a functional food supplement for colon health.
Guangjian Jiang
Beijing University of Chinese Medicine, China
Title: Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes
Biography:
Guangjian Jiang has received her BS from North China Coal Medical University and PhD in Medical Science from Hebei Medical University. She has completed Post doctorate training in State Key Laboratory of Reproductive Biology, The Institute of Zoology of Chinese Academy of Sciences and worked as a Post Doctor at Harvard University Medical School Beth Israel Deaconess Medical Center in Boston. She has worked as a Dean of Department of Biochemistry and Molecular Biology in North China University of Science and Technology. Currently, she is a Professor in Diabetes Research Center, Beijing University of Chinese Medicine. Her research interests include natural medicine (traditional Chinese medicine) treatment of chronic disease and majored in molecular and cellular mechanisms of diabetes, cancer and age-associated degenerative diseases. She has focused on the Epigenetics, Traditional Chinese Medicine and Reproductive Biology areas.
Abstract:
Browning of white adipocyte tissue (WAT) has received considerable attention due to its potential implication in preventing obesity and related comorbidities. Ginsenoside Rb1 is reported to improve glycolipid metabolism and reduce body weight in obese animals. However whether the body reducing effect mediates by browning effect remains unclear. For this purpose, 3T3-L1 adipocytes were used to study the effect of ginsenoside Rb1 on browning adipocytes specific genes and oxygen consumptions. The results demonstrate that 10 mM of ginsenoside Rb1 increases basal glucose uptake and promoted browning evidenced by significant increases in mRNA expressions of UCP-1, PGC-1a and PRDM16 in 3T3-L1 mature adipocytes. Further, ginsenoside Rb1 also increases PPARγ activity. And the browning effect is abrogated by GW9692, a PPARγ antagonist. In addition, ginsenoside Rb1 increases basal respiration rate, ATP production and uncoupling capacity in 3T3-L1 adipocytes. Those effects are also blunted by GW9692. The results suggest that ginsenoside Rb1 promote browning of 3T3-L1 adipocytes through induction of PPARγ. Our finding offer a new source to discover browning agonists and also useful to understand and extend the applications of ginseng and its constituents.
Baodong Zheng
Fujian Agriculture and Forestry University, China
Title: Sensory and nutritional properties of chinese olive pumace based high fiber biscuit
Biography:
Baodong Zheng has completed his PhD from Fujian Agriculture and Forestry University. He is the Dean of College of Food Science, Fujian Agriculture and Forestry University. He has published more than 20 papers in reputed journals and has been serving as the Editorial Board Member of Journal of Toxicology.
Abstract:
Consumer interest in healthy eating is shifting towards the potential health benefits of specific foods and food ingredients. Unconventional ingredients combined with usual bakery flour yields better acceptable, healthy and nutritious bakery products. The present study aims to evaluate the sensory and nutritional properties of Chinese olive pumace based high fiber biscuit. The high fiber biscuit was formulated using Chinese olive pumace powder (15%), wheat (100 g), sugar powder (33%) and spices after repeated trials and the recipe was standardized. When subjected to sensory evaluation, the newly formulated high fiber biscuit derived a score of 4.5±0.51, out of a maximum score of 5, for its overall acceptability, indicating the biscuit was well accepted. The results of the nutritional quality and cost of the newly formulated high fiber biscuit showed that it contains the 10.20 g fiber, 1454 Kcal calories and 18.30 g fat in 100 g biscuit. Furthermore, the glycemic index (GI) results indicated that GI of olive high fiber biscuits was 63.68 which was significantly lower than the control one with the GI value of 76.66. Besides, the physical and chemical indicators as well as the microbiological indicators were also up to the Chinese national standards (GB/T20980-2007 and GB7100-2003). Hence, the study proved that the newly formulated olive pumace powder based biscuit is well acceptable based on its sensory properties and fiber rich nutritional quality.
Baodong Zheng
Fujian Agriculture and Forestry University, China
Title: Sensory and nutritional properties of chinese olive pumace based high fiber biscuit
Biography:
Baodong Zheng has completed his PhD from Fujian Agriculture and Forestry University. He is the Dean of College of Food Science, Fujian Agriculture and Forestry University. He has published more than 20 papers in reputed journals and has been serving as the Editorial Board Member of Journal of Toxicology.
Abstract:
Consumer interest in healthy eating is shifting towards the potential health benefits of specific foods and food ingredients. Unconventional ingredients combined with usual bakery flour yields better acceptable, healthy and nutritious bakery products. The present study aims to evaluate the sensory and nutritional properties of Chinese olive pumace based high fiber biscuit. The high fiber biscuit was formulated using Chinese olive pumace powder (15%), wheat (100 g), sugar powder (33%) and spices after repeated trials and the recipe was standardized. When subjected to sensory evaluation, the newly formulated high fiber biscuit derived a score of 4.5±0.51, out of a maximum score of 5, for its overall acceptability, indicating the biscuit was well accepted. The results of the nutritional quality and cost of the newly formulated high fiber biscuit showed that it contains the 10.20 g fiber, 1454 Kcal calories and 18.30 g fat in 100 g biscuit. Furthermore, the glycemic index (GI) results indicated that GI of olive high fiber biscuits was 63.68 which was significantly lower than the control one with the GI value of 76.66. Besides, the physical and chemical indicators as well as the microbiological indicators were also up to the Chinese national standards (GB/T20980-2007 and GB7100-2003). Hence, the study proved that the newly formulated olive pumace powder based biscuit is well acceptable based on its sensory properties and fiber rich nutritional quality.